I took a week off once and ended up married.   Actually, our wedding and honeymoon were the first and only week I had off in a decade.

I had a colleague, whom I've known and contracted out to, cover for my day-to-day activities.  He did so competently and stayed in contact with me via text and email (easy and discreet to review without tipping anyone off that i was doing actual "work");  have your emails forwarded to your cellphone for the duration, but keep your ringer on vibrate so as not to tip off the loved ones.  if you dont have a cell phone, invest in a prepaid one for $20 plus the air time at Best Buy or 7-11 or online at a big box store... get one with the texting option, if your "fill-in" is going to be sending you information, other than by voicemail.

I answered emails once a day and kept an out of office auto-reply active for the week.  I also informed my regulars well in advance.  I used one of the new $250 mini-notebooks with the hotel's free wi-fi service, so shop you hotels for that too.  Note:  getting up an hour before your "significant other" is a great time in the early AM to surf, check emails, reply to things and still go out and get breakfast for them in bed.

I did not have to worry about my contractor as he was a long-time friend and I, none-the-less, made sure that I had a nondisclosure, noncompetiion paper in place so that everyone felt secure.  He was also trained and versed in my research and work flow, so I just needed to do a quick 10-minute refresher with him.

With online Grantor-Grantee, Assessors rolls, Tax rolls, GIS systems, Google Maps, and services like HomeInfoMax.com (that gets you back to about 1980 in title chains for most of California), plus someone (my contractor) to call on during the day, I was in pretty good shap and all went well.

I also checked the local news (to my home area of work) nightly, just to make sure nothing new was occuring that might affect business or my contractors' access.  Know your contractors work flow too, just in case you get delayed by bad weather, if flying (keep an eye on weather news too).

Keep contigency plans in place.  Check in regularly.  Send "heads-ups".  Post notice.   Keep resources at your finger tips.